Leland H. Hartwell

HARTWELL, LELAND H.

President and Director of the the Fred Hutchcinson Cancer Research Center, Seattle, WA, USA,
Professor of Genetics in the College of Arts & Sciences and adjunct professor of medicine at the University of Washington,
American Cancer Society Research Professor of Genetics.

Research interests :
His work over the last 30 years, using yeast as a model organism, forms the foundation upon which today's detailed knowledge of the molecular mechanisms controlling the cell division cycle in nucleated cells rests. Dr. Hartwell's discovery of genes regulating the orderly progression of the cell cycle has had a major influence on our understanding of cancer and the therapeutic strategies used to treat diseases caused by uncontrolled cell growth.

Leland H. Hartwell is widely recognized as a pioneer in the field of yeast genetics and cancer research. Since then, his discoveries have profoundly affected the understanding of human cell growth and cancer. He and his colleagues are studying yeast cells to determine if lack of a cell's control over certain points in its division sequence may contribute to cancer. He also is examining the role of hormones in controlling cell growth.

Awards :
2001 Nobel Prize in physiology or medicine, 2000 Massry Prize, 2000 Leopold Griffuel Prize, 1999 American Cancer Society Medal of Honor Basic, 1999 Research Award, 1999 City of Medicine Award, 1999 California Institute of Technology -Distinguished Alumni Award, 1998 Albert Lasker Basic Medical Research Award, 1998 Brinker International Award for Basic Science (Susan G. Komen Breast Cancer Foundation), 1996 Carnegie Mellon Dickson Prize, 1996 Passano Award, 1995 Keith Porter Award, American Society of Cell Biology, 1995 Columbia University Horowitz Award, 1996 MGH Warren Triennial Prize, 1994 Genetics Society of America Medal, 1994 Sloan-Kettering Cancer Center Katherine, 1994 Berkan Judd Award, 1993 Brandeis University Rosenstiel Award, 1992 University of Chicago Simon Shubitz Award, Gairdner Foundation International Award, 1991 Hoffman LaRoche Mattia Award, General Motors Sloan Award, 1990 National Institutes of Health Merit Award, 1990-present American Cancer Society Research Professor, Genetics
1983-1984 Guggenheim Awardee and American Cancer, 1973 Eli Lilly Award in Microbiology and Immunology.

Selected publications :
Simon JA; Szankasi P; Nguyen DK; Ludlow C; Dunstan HM; Roberts CJ; Jensen EL; Hartwell LH; Friend SH. Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiae.. Cancer Res. 60(2): 328-33, 15 2000

Simon, J.A., Szankaski, P., Nguyen, D.K., Ludlow, C, Dunstan, H.M., Roberts, C.J., Jensen, E.L., Hartwell, L.H., Friend, S.H.. Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiae. Cancer Research. 60(2): 328-333, 2000

Hartwell, L.H., Hopfield, J.J., Leibler, S., Murray, A.W.. From molecular to modular cell Biology. Nature 402 supplement. 6761: C47-C52, 1999

Marton MJ, DeRisi JL, Bennett HA, Iyer VR, Meyer MR, Roberts CJ, Stoughton R, Burchard J, Slade D, Dai H, Bassett DE Jr, Hartwell LH, Brown PO, Friend SH. Drug target validation and identification of secondary drug target effects using DNA microarrays. Nature Medicine. 4(11): 1293-301, Nov 1998

Paulovich AG, Armour CD, Hartwell LH. The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage. Genetics. 150(1): 75-93, Sep 1998