Research Professor, Department of Biochemistry, Technion - Israel Institute of Technology, Rappaport Institute, Haifa, Israel.
Research Interests : 1- Regulation of the transcriptional regulators NF-kB, Myc, p53 and MyoD by the ubiquitin system.
2- On the linkage between the ubiquitin system and apoptosis. Downregulating the ubiquitin system and resensitizing malignant cells to apoptosis as a measure to reverse the malignant phenotype.
Awards and Honors : Nobel Prize in Chemistry for 2004 "for the discovery of ubiquitin-mediated protein degradation" awarded jointly to Prof. Avram Hershko and Prof. Irwin Rose.
Selected Publications : Journal Articles
Ciechanover A.
The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for mechanism-based drug targeting.,
Biochem Soc Trans. 2004 Oct 14;132(3):103-107
Nadav E, Shmueli A, Barr H, Gonen H, Ciechanover A, Reiss Y.
A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1.,
Biochem Biophys Res Commun. 2004 Oct 14;132(3):103-107
Lingbeck JM, Trausch-Azar JS, Ciechanover A, Schwartz AL.
Determinants of nuclear and cytoplasmic ubiquitin-mediated degradation of MyoD.,
J Biol Chem. 2004 Oct 14;132(3):103-107
Herrmann J, Edwards WD, Holmes DR Jr, Shogren KL, Lerman LO, Ciechanover A, Lerman A.
Increased ubiquitin immunoreactivity in unstable atherosclerotic plaques associated with acute coronary syndromes.,
J Am Coll Cardiol. 2004 Oct 14;132(3):103-107
Ryoo HD, Bergmann A, Gonen H, Ciechanover A, Steller H.
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.,
Nat Cell Biol. 2004 Oct 14;132(3):103-107
Amir RE, Iwai K, Ciechanover A.
The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105.,
J Biol Chem. 2004 Oct 14;132(3):103-107
Glickman MH, Ciechanover A.
The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.,
Physiol Rev. 2004 Oct 14;132(3):103-107
CIECHANOVER, AARON 